How to make CBD use in cancer patients safer?
Complementary medicine becomes support of a large fraction of patients dealing with cancer. They often use agents which can lower their anxiety, pain, and insomnia. One of the safest and most effective agents is CBD.
Instead of non-addictive CBD from reliable sources, some patients opt for cannabis without checking THC amount. Several also opt for herbal supplements, yoga, acupuncture, special diets and mindfulness meditation.
CBD oils increasingly are being sold online and by retailers. The FDA and various European bodies do not evaluate the safety and efficacy of CBD products prior to their introduction in the market. Most countries have removed hemp from controlled substances, when cannabis plants and derivatives contain only low THC on a dry weight basis.
Use of CBD products by patients with cancer is most likely to be as self-care for symptom management. Adverse effects associated with CBD use typically are minor and mild. The most common include somnolence.
The FDA and CDC recommend that consumers not use THC-containing vaporization products — especially from informal sources like friends, family or online dealers. Further, because CBD vaporization products have been found to be adulterated with THC, if one opts for one, should be from a reliable source.
Bonn-Miller and colleagues evaluated labeling of CBD products (ie, oils, tinctures and vaporization liquids) relative to laboratory-analyzed concentration of CBD. The results, published in 2017 in JAMA, showed only 30.9% of products were labeled accurately.
Oils were the most accurately labeled and vaporization liquids were least accurately labeled. Further, high THC was detected in 21.4% of products analyzed.
Investing in a relationship with the patient will support safe use of CBD oil products, as providers and patients can freely share information about their use. Shared decision-making informed by evidence then can be employed regarding CBD oil use and whether it is safe in the context of a patient’s cancer care plan.
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References:
- Academic Consortium for Integrative Medicine & Health. Introduction. Available at: imconsortium.org/about/introduction. Accessed on Sept. 16, 2020.
- Bonn-Miller MO, et al. JAMA. 2017;doi:10.1001/jama.2017.11909.
- CDC. Outbreak of lung injury associated with the use of e-cigarette, or vaping, products. Available at: www.cdc.gov/tobacco/basic_information/e-cigarettes/severe-lung-disease.html. Accessed on Aug. 14, 2020.
- Donvito G, et al. Neuropsychopharmacology. 2018;doi:10.1038/npp.2017.204.
- FDA. FDA regulation of cannabis and cannabis-derived products, including cannabidiol (CBD). Available at: www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbd. Accessed on Sept. 16, 2020.
- Good P, et al. BMC Palliat Care. 2019;doi:10.1186/s12904–019–0494–6.
- Kis B, et al. Int J Mol Sci. 2019;doi:10.3390/ijms20235905.
- Manion CR and Widder RM. Am J Health Syst Pharm. 2017;doi:10.2146/ajhp151043.
- Martell K, et al. Curr Oncol. 2018:doi:10.3747/co.25.3983.
- Mücke M, et al. J Cachexia Sarcopenia Muscle. 2018;doi:10.1002/jcsm.12273.
- National Center for Complementary and Integrative Health. Cannabis (marijuana) and cannabinoids: What you need to know. Available at: www.nccih.nih.gov/health/cannabis-marijuana-and-cannabinoids-what-you-need-to-know. Accessed on Sept. 16, 2020.
- NCI. Aromatherapy with essential oils (PDQ) — Health Professional Version. Available at: www.cancer.gov/about-cancer/treatment/cam/hp/aromatherapy-pdq. Accessed on Aug. 14, 2020.
- Sanford NN, et al. JAMA Oncol. 2019;doi:10.1001/jamaoncol.2019.0349.
- VanDolah HJ, et al. Mayo Clin Proc. 2019;doi:10.1016/j.mayocp.2019.01.003.
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